The Orange Pill Podcast

Episode 144- Ashwagandha Under the Microscope: What a 12-Week Trial Really Found

Ashwagandha has become synonymous with stress relief, but what happens when you put that claim through a placebo-controlled clinical trial? A 12-week randomized, double-

Episode 143- Same Supplement. Opposite Outcome: When Biological Sex Changes the Science

Can the same supplement produce completely opposite biological effects depending on sex? A 2026 preclinical study investigating calcium alpha-ketoglutarate (Ca-αKG) in m

Episode 142- The Supplementation of America: How Targeted Health Became a Majority Habit

Dietary supplements are no longer a niche wellness habit. According to a new 2026 report from the National Center for Health Statistics, 60.2% of U.S. adults used at leas

Episode 141- IBS Is More Than a Gut Problem: What an 8-Week Probiotic Trial Revealed

IBS isn't simply a digestive disorder, it's increasingly understood as a complex disorder of gut-brain interaction. An 8-week randomized, double-blind, placebo-controlle

Episode 140- GLP-1 Agonists and Thiamine Deficiency: An Overlooked Nutritional Risk?

GLP-1 receptor agonists have transformed the conversation around obesity and metabolic health. But as their use continues to grow, researchers and clinicians are beginnin

Episode 139- The 12-Week Metabolic Reset: Why Soluble Fiber Is the Quiet Powerhouse of Weight Management

Fiber isn't just about digestive health. A systematic review and meta-analysis of 27 randomized controlled trials involving more than 1,400 participants found that solub

Episode 138- Beyond the Bench Press: The Surprising Science of How Creatine Powers Your Brain

Creatine may be famous for building muscle but its next frontier could be the brain. A 2024 systematic review and meta-analysis of 16 randomized controlled trials found

Episode 137- The Calcium Slowdown: Can Vitamin K2 Change the Course of Arterial Aging?

What if the hardening of our arteries isn't entirely inevitable? A two-year study investigated whether vitamin K2 as MK-7 could influence the progression of coronary art

Episode 136- The Sunscreen You Swallow? New Science on Protecting Skin From Within

  A 2025 randomized, double-blind, placebo-controlled trial explored whether a combination of Polypodium leucotomos, Red Orange extract, and vitamins could help strength

Episode 135- The Hidden Price of Safety: Why the FDA’s New Food Rule Costs More Than They’re Telling You

What does it really cost to make GRAS notification mandatory? The FDA’s proposed GRAS overhaul promises greater transparency, but the headline numbers may not tell the w

Episode 134- The World’s Most Expensive Spice Might Be the Secret to Fighting “Low Mood”: 5 Surprising Findings from the Largest Saffron Study to Date

What if one of the world’s oldest, and most expensive spices could have a measurable impact on the everyday “gray zone” of mental health? In Episode 134 of the Orange Pi

Episode 133- RFK Jr. and the Future of America's Food Pantry

A proposed FDA rule could fundamentally change how new food ingredients enter the U.S. marketplace. In Episode 133 of the Orange Pill Podcast, we unpack the FDA's propos

Episode 132- The Sweet Science of Better Digestion: Why Prebiotic FOS Is Outshining Traditional Laxatives

Millions of people struggle with constipation, yet many still rely on laxatives that simply force the digestive system into action. In Episode 132 of the Orange Pill Pod

Episode 131- The KGK Design Intelligence Lab: How Math Is Replacing Guesswork in Clinical Trials

Clinical trials are essential, but choosing the wrong dose, population, or endpoint can derail a study before it begins. In Episode 131 of the Orange Pill Podcast, we in

Episode 130- The Quercetin Paradox: Why Performance Supplements Aren't Always What They Seem

Can one of the world's most researched plant compounds actually improve athletic performance, or have we been asking the wrong question? In this episode of the Orange Pi

Episode 129- The End of America's Food Innovation Era?

For decades, America's food innovation system has relied on the self-GRAS pathway, allowing companies to determine the safety of new ingredients without mandatory FDA not

Episode 128- The Death of the Average Diet: Why Personalized Nutrition Is the Future

Why do two people eating the exact same meal have completely different metabolic responses? In this episode of the Orange Pill Podcast, we explore the groundbreaking PRE

Episode 127- Utah's New Regulatory Frontier: Is Your Melatonin Next?

A new Utah law is expanding the definition of "specialized products", and the implications could extend well beyond cannabinoids and nicotine. In this episode of the Ora

Episode 126-Beyond the Hype: What a New Saffron Study Reveals About Everyday Mood

Feeling "fine" isn't always the same as feeling your best. In this episode of the Orange Pill Podcast, we explore groundbreaking research showing how a standardized saff

Episode 125- The Chemical Labyrinth: Is America’s Food Reform Movement Losing Momentum?

The push to "Make America Healthy Again" promised sweeping changes to the U.S. food supply, but turning bold ideas into federal policy is proving far more complex. In th