The Orange Pill Podcast

Episode 150- Can We Slow Cellular Aging? The Science of NAD+, CD38 & DailyColors®

What if supporting healthy aging isn't just about producing more NAD+, but also understanding why our cells lose it in the first place? In Episode 150 of The Orange Pill

Episode 149: FDA Finalizes NDI Guidance - What Does It Mean for the Supplement Industry?

The FDA has finalized its guidance on identity and safety information for New Dietary Ingredient Notifications (NDINs). But what does this mean for the dietary supplement

Episode 148- Can We Turn Back the Cellular Clock? What the DO-HEALTH Longevity Trial Revealed

What if slowing biological aging didn't require expensive treatments or extreme lifestyle changes? In Episode 148 of The Orange Pill Podcast, we explore findings from th

Episode 147- Beyond the Gym: Creatine's Surprising Effects on Sleep, Focus, and Performance

Creatine is best known for building muscle and boosting athletic performance, but could its benefits extend beyond the gym? In this episode of The Orange Pill Podcast, w

Episode 146- The Plant-Powered Recovery Revolution: Can Polyphenols Help Muscles Bounce Back Faster?

What if your muscles could regain strength before the soreness disappears? Emerging research suggests that plant-derived polyphenols may influence exercise recovery in w

Episode 145- The Golden Root Glitch: When Less Rhodiola Delivered More

When it comes to supplements, we often assume that a higher dose means a bigger effect. A 2025 randomized, double-blind crossover trial of Rhodiola rosea challenges that

Episode 144- Ashwagandha Under the Microscope: What a 12-Week Trial Really Found

Ashwagandha has become synonymous with stress relief, but what happens when you put that claim through a placebo-controlled clinical trial? A 12-week randomized, double-

Episode 143- Same Supplement. Opposite Outcome: When Biological Sex Changes the Science

Can the same supplement produce completely opposite biological effects depending on sex? A 2026 preclinical study investigating calcium alpha-ketoglutarate (Ca-αKG) in m

Episode 142- The Supplementation of America: How Targeted Health Became a Majority Habit

Dietary supplements are no longer a niche wellness habit. According to a new 2026 report from the National Center for Health Statistics, 60.2% of U.S. adults used at leas

Episode 141- IBS Is More Than a Gut Problem: What an 8-Week Probiotic Trial Revealed

IBS isn't simply a digestive disorder, it's increasingly understood as a complex disorder of gut-brain interaction. An 8-week randomized, double-blind, placebo-controlle

Episode 140- GLP-1 Agonists and Thiamine Deficiency: An Overlooked Nutritional Risk?

GLP-1 receptor agonists have transformed the conversation around obesity and metabolic health. But as their use continues to grow, researchers and clinicians are beginnin

Episode 139- The 12-Week Metabolic Reset: Why Soluble Fiber Is the Quiet Powerhouse of Weight Management

Fiber isn't just about digestive health. A systematic review and meta-analysis of 27 randomized controlled trials involving more than 1,400 participants found that solub

Episode 138- Beyond the Bench Press: The Surprising Science of How Creatine Powers Your Brain

Creatine may be famous for building muscle but its next frontier could be the brain. A 2024 systematic review and meta-analysis of 16 randomized controlled trials found

Episode 137- The Calcium Slowdown: Can Vitamin K2 Change the Course of Arterial Aging?

What if the hardening of our arteries isn't entirely inevitable? A two-year study investigated whether vitamin K2 as MK-7 could influence the progression of coronary art

Episode 136- The Sunscreen You Swallow? New Science on Protecting Skin From Within

  A 2025 randomized, double-blind, placebo-controlled trial explored whether a combination of Polypodium leucotomos, Red Orange extract, and vitamins could help strength

Episode 135- The Hidden Price of Safety: Why the FDA’s New Food Rule Costs More Than They’re Telling You

What does it really cost to make GRAS notification mandatory? The FDA’s proposed GRAS overhaul promises greater transparency, but the headline numbers may not tell the w

Episode 134- The World’s Most Expensive Spice Might Be the Secret to Fighting “Low Mood”: 5 Surprising Findings from the Largest Saffron Study to Date

What if one of the world’s oldest, and most expensive spices could have a measurable impact on the everyday “gray zone” of mental health? In Episode 134 of the Orange Pi

Episode 133- RFK Jr. and the Future of America's Food Pantry

A proposed FDA rule could fundamentally change how new food ingredients enter the U.S. marketplace. In Episode 133 of the Orange Pill Podcast, we unpack the FDA's propos

Episode 132- The Sweet Science of Better Digestion: Why Prebiotic FOS Is Outshining Traditional Laxatives

Millions of people struggle with constipation, yet many still rely on laxatives that simply force the digestive system into action. In Episode 132 of the Orange Pill Pod

Episode 131- The KGK Design Intelligence Lab: How Math Is Replacing Guesswork in Clinical Trials

Clinical trials are essential, but choosing the wrong dose, population, or endpoint can derail a study before it begins. In Episode 131 of the Orange Pill Podcast, we in