Lifespan with Dr. David Sinclair is a health and science show on how to live longer and stay healthier - grounded in the latest longevity research.
A Professor of Genetics for over 25 years at Harvard Medical School and a leader in the field of longevity research, Dr. Sinclair breaks down the latest studies into clear, applicable insights so that you can perform at your best and live your longest, healthiest life.
Season 1 ranked #1 in Health & Wellness podcasts. Season 2 is now live, starting with two Rewind episodes, followed by new episodes detailing the latest breakthroughs in aging science.
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New episodes every two weeks.
Latest episodes
Showing 20 · updated from the feed
Are GLP-1s the First Longevity Drugs? | Lifespan with Dr. David Sinclair - S2, Ep. 11
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.
Oct 4 1 h 00 min
This Sugar Substitute May Extend Your Life | Lifespan with Dr. David Sinclair - S2, Ep. 9
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.
Sep 19 49 min
This Sugar Substitute May Extend Your Life | Lifespan with Dr. David Sinclair - S2, Ep. 9
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.
Sep 19 1 h 11 min
How to Eat for Gut Health & Longevity | Lifespan with Dr. David Sinclair - S2, Ep. 8
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.
Sep 11 31 min
Why We Age | Lifespan with Dr. David Sinclair - S2, Ep. 7
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.
Sep 4 30 min
Why Exercise Slows Aging | Lifespan with Dr. David Sinclair
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.
Aug 21 1 h 11 min
How to Exercise to Live Longer | Lifespan with Dr. David Sinclair - S2, Ep. 5
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.
Aug 7 1 h 09 min
Inside the World’s First Age Reversal Trial | Lifespan with Dr. David Sinclair - S2, Ep. 4
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.
Jul 23 1 h 12 min
What to Eat & When to Eat for Longevity: New Science | Lifespan with Dr. David Sinclair - S2, Ep. 3
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives - while supporting medical research into breakthroughs to improve all live
Jul 12 1 h 08 min
Fasting as a Path to Longevity: The Facts | Lifespan with Dr. David Sinclair - Season 2, Episode 2
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.
Jun 25 1 h 15 min
The Longevity Revolution Is Here | Lifespan with Dr. David Sinclair - Season 2, Episode 1
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.
Jun 25 1 h 06 min
The Most Surprising Longevity Discoveries | Lifespan with Dr. David Sinclair Rewind
What are the most important things you can do today to live longer and stay healthier while doing it?
In this final Lifespan Rewind episode, Dr. David Sinclair, A.O., Ph
May 21 1 h 16 min
Season 2 Official Trailer: Lifespan with Dr. David Sinclair
What if aging is more reversible than we once thought?
Season 2 of Lifespan with Dr. David Sinclair, A.O., Ph.D., explores the latest breakthroughs in longevity science
May 18 1 min
What To Do For Longevity | Lifespan with Dr. David Sinclair Rewind
What are the most important things you can do today to live longer and stay healthier while doing it?
In this first Lifespan Rewind episode, Dr. David Sinclair, A.O., Ph
May 6 59 min
Biotracking, Age Reversal & Other Advanced Health Technologies | Episode 8
In the final episode of this season, Dr. David Sinclair and Matthew LaPlante focus on current and near-future technologies relevant to health and aging. In addition to di
Feb 23 2022 1 h 09 min
The Science of Keeping the Brain Healthy | Episode 7
In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain
Feb 16 2022 1 h 01 min
The Science of Looking Younger, Longer | Episode 6
In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why
Feb 9 2022 1 h 09 min
Medical Interventions (TRT, HGH, Stem Cells, Peptides, etc.) For Longevity | Episode 5
In this week’s episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante cover potential anti-aging interventions that are on the cutting edge. The
In this week’s episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share th
Jan 26 2022 1 h 10 min
Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3
In Episode 3 of the Lifespan Podcast, Dr. David Sinclair and Matthew LaPlante dive deeply into the science of non-dietary interventions that mimic adversity and promote h
Jan 19 2022 1 h 11 min
Chart trend
Position in the Health & Fitness chart (US), last 90 days.
#1#101#200JulAugSepOct
#25
all-time peak
14
days in the top 50 since Dec 2024
Chart positions
Where Lifespan with Dr. David Sinclair ranks today in each Apple Podcasts chart (US, Oct 11, 2026).
A curated, balanced selection of Apple Podcasts reviews.
I’ve been a fan of Dr. Sinclair since hearing him on Armchair Expert years ago. This pod is an excellent addition to his book. (One request: Please include a notice that an ad is incoming. Without a notification, it feels like we’re being tricked, which is disengenuine to the ethos of the podcast.)
Thelazyninja · Aug 2026
It is so gross how Dr Sinclair inserts ads directly into the conversation. It would be helpful if there was a clear break when he is doing ads. It undermines his credibility and the podcast. Im genuinely interested in what he endorses, but want it absolutely clear what he profits from and what he does not.
e2988 · Jun 2026
Such hopeful research! My daughter’s optic nerves were crushed by a brain tumor, and listening to you talk about your aging research beginning with fixing loss of sight is just amazing. Brought me to tears thinking of the possibilities for her, hopefully sooner than later. I loved every episode of this series and can’t wait for the next season.
JayneSays · May 2026
Smart, evidence-based insights. No fluff - just simple, practical takeaways that you can actually use. Can’t wait for Season 2.
jcchadwick · Mar 2026
There is no break in the podcast to indicate an ad. Instead, they are woven into the discussion. That practice is a complete turnoff and seriously undermines any advice or message. I refuse to listen to any more episodes of Season 2 as a result
TheHesitantReviewer · Aug 2026
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About Lifespan with Dr. David Sinclair on Reason.fm
Here you find the Apple Podcasts chart positions of Lifespan with Dr. David Sinclair, its latest episodes to listen to directly, and reviews from listeners. Rankings are updated daily for the United States.
