MeSsy with Christina Applegate & Jamie Lynn Sigler

Latest episodes

Showing 20 · updated from the feed

Jack Osbourne

#5 trending · Personal Journals

This week, Christina and Jamie are joined by Jack Osbourne for an honest conversation about growing up in the spotlight, getting sober at 17, and being diagnosed with MS

Nov 3
52 min

We're All Just Living This MeSsy Life

This week, Christina and Jamie read listener emails and discuss navigating life without a diagnosis, the challenges of parenting teenagers, learning to accept help, and t

Oct 27
50 min

Christina Is Back (Part 2) with Dr. Marwa Kaisey

In part two of their conversation, Jamie and Christina are joined by Dr. Marwa Kaisey, an Associate Professor of Neurology at Cedars-Sinai in Los Angeles. Send us an ema

Oct 20
44 min

Christina Is Back (Part 1)

Christina is finally back! This week, she returns to MeSsy and joins Jamie to catch up on everything that’s been going on in her life over the past six months. Send us a

Oct 20
35 min

Learning to Love Every Version of Yourself with Tiffani Thiessen

This week, Jamie is joined by Tiffani Thiessen. They talk about growing up in the spotlight, navigating rejection, embracing aging, and learning to love every version of

Oct 13
54 min

What If You’re Not Stuck, You’re Just in Between? with Emmanuelle Chriqui

This week, Jamie is joined by her friend, actress Emmanuelle Chriqui. They talk about grief, the friendships that carry us through hard times, getting older, learning to

Oct 6
57 min

I Don’t Have a Lot of Fight in Me Right Now

This week, Jamie reads listener emails and discusses parenting with MS, learning to embrace mobility aids, and navigating unsolicited advice and comparisons. Executive

Sep 29
31 min

How to Live With What You Can’t Control with Ana Rodriguez

In the final episode of Living With It, Jamie sits down with her therapist, Ana Rodriguez, to talk about what it really means to heal when life doesn’t go according to pl

Sep 24
59 min

The Hardest Fight Is Learning to Rest with Alberto Crane

This week, Jamie sits down with jiu-jitsu champion and former UFC fighter Alberto Crane to talk about how his MS diagnosis forced him to redefine what it means to be stro

Sep 22
41 min

Stop Apologizing for Wanting More with Heather Dubrow

This week on Living With It, Jamie sits down with Heather Dubrow for an honest conversation about embracing life’s pivots, protecting your peace, and giving yourself perm

Sep 17
54 min

There Is Beauty Within All of This Pain with Lindsey Kraft

This week on MeSsy, Jamie sits down with her longtime friend, actress, writer, and musician Lindsey Kraft. They talk about growing up together, navigating rejection and s

Sep 15
54 min

Falling Apart to Come Back Together with Ryan Weiss

This week on Living With It, Jamie sits down with her friend, Ryan Weiss. They talk about letting go of control, sitting with difficult emotions, knowing when it’s time t

Sep 10
47 min

Thank God I’m So Neurotic with Cat Cohen

This week on MeSsy, Jamie sits down with comedian, actor, and singer Cat Cohen. Cat opens up about having a stroke at 31, navigating health anxiety in the aftermath, and

Sep 8
47 min

We Fight For Joy with Kelsey Chittick

This week on Living With It, Jamie sits down with Kelsey Chittick to talk about losing her husband suddenly, raising two children through grief, and learning to build a l

Sep 3
53 min

There’s No Place Like Home with Annie Meyers-Shyer

This week, Jamie is joined by her longtime friend Annie Meyers-Shyer, the creator behind This Oak House. They talk about Annie’s unexpected second act, finding a new pass

Sep 1
53 min

The Power of Radical Acceptance with Jim Curtis

This week on Living With It, Jamie sits down with Jim Curtis, a transformational coach, author, and wellness leader. They discuss how to radically accept the life you hav

Aug 27
53 min

Jamie's Son Beau

This week, Jamie sits down with a very special guest: her 13-year-old son, Beau. They have an honest conversation about what it’s been like growing up with a mom who has

Aug 25
42 min

Accept, Adapt, Appreciate with Odette Annable

This week on Living With It, Jamie sits down with her friend Odette Annable. They discuss parenting a neurodivergent child, trusting your instincts, advocating for your f

Aug 20
54 min

The Courage to Slow Down

This week on MeSsy, Jamie opens up about reaching her limit and learning to make rest part of healing. She also reads listener emails about fighting to be heard by doctor

Aug 18
53 min

Finding Stillness When Life Won’t Slow Down with Bob Roth

This week on Living With It, Jamie sits down with Bob Roth, a leading Transcendental Meditation teacher and CEO of the David Lynch Foundation. They discuss what stress do

Aug 13
1 h 00 min

Chart trend

Position in the Personal Journals chart (US), last 90 days.

#1#19#37AugSepOctNov

all-time peak

days in the top 3 since Nov 2024

Chart positions

Where MeSsy with Christina Applegate & Jamie Lynn Sigler ranks today in each Apple Podcasts chart (US, Nov 5, 2026).

#9 ▲ 3 Personal Journals US

#127 ▲ 41 Society & Culture US

What listeners say

A curated, balanced selection of Apple Podcasts reviews.

I recently discovered this podcast a few months ago. I have many episodes to go back to ! While I don’t have MS, Ive had chronic lyme for decades and am remission from lung cancer. I appreciate the raw and real talk, connections with actual people, the guests who share their stories, and the relatability of both ladies. While none of us with diagnoses and symptoms want to identify with what they are , it is refreshing to feel Im not alone in living with chronic anything while continuing to build and live a meaningful life. Ive also listened to both books. It is strange to feel I know these ladies even through their books with millions of others but that’s what it feels like on this side- Thank you, Christina & Jamie! And miss you Christina-

Moongirl7364 · Sep 2026

I can’t believe how long it took me to find this podcast. I’m so happy I did! I also am only on the 20th episode, so I’m so happy I have so many more. I just finished both books. They were incredibly inspirational and eye opening. I can relate to both of you and I wish I could be best friends with you both! I have very similar symptoms, especially with my legs. I can relate to staying in bed. It’s my safe place. I am surrounded by amazing family and friends, but have felt so alone in my diagnosis. I thought maybe it was MS, but the diagnosis was Peripheral Neuropathy. I feel blessed beyond belief to have found you two and to have the honor and privilege of reading your books and now feeling so much support from MeSsy. Thank you! Jill- also a lifelong Palisadian

Jillali18 · Jul 2026

I don’t have a significant other, husband or boyfriend, but I do have brothers who are acting as my caregivers. This episode hit close to home because I recognize a lot of their challenges and struggles in what Cutter shared during your conversation. Jaime thanks for all the prep you did. Your questions were totally on point. You may have said it was couple’s therapy but I believe a better description is relationship strengthening. Thanks for the suggestions/advice and example of good, healthy communication.

Lisard01 · May 2026

I’ve been listening to this podcast since they started it and absolutely love their pure honesty and I’m constantly shocked at all they have to go through, it’s eye opening! Today’s episode with Jaime Lynn’s husband was just SO incredibly beautiful! He’s so honest and supportive and hearing him speak about her is just the best thing! I was teary through the whole episode, you girls always get me too. His support and love is THE MOST beautiful thing! Thank you for sharing! And Jamie Lynn, you were absolutely stunning on Grey’s Anatomy, I had forgotten about you being on and I was multitasking while watching and I heard your voice and got this warm fuzzy feeling and couldn’t figure out why, since you were a new character on the show! And then I looked up and saw YOU! Such a strong and powerful woman you played and that you actually are in real life too! Thank you for sharing your true lives with us! I’ve been a fan of you Christina for as long as I can remember, and I’m older than you, ha!

lcpeebles · Apr 2026

We strive to present a balanced view by showing a diverse range of reviews from Apple Podcasts.