The Pauling Principle

The Pauling Principle Episode 30 - Open Science with Karmen Čondić-Jurkić

In this episode I sit down with Karmen Čondić-Jurkić, co-founder and Executive Director of the Open Molecular Software Foundation, the organization behind OpenFE, Open Fo

The Pauling Principle - Episode 28

I sat down with Christopher Bradley, CEO and Co-Founder of Matter Bio, a company working at the intersection of longevity science and oncology. Christopher co-founded Mat

The Pauling Principle Episode 27 - Longevity Medicine with Andrea Maier

Most doctors treat you after you get sick. Professor Andrea Maier is trying to make sure you never get there. In this episode, I sit down with one of the world's leading

The Pauling Principle Episode 29 - Targeting the pathological cells that drive aging

In this episode of The Pauling Principle I sit with Marco Quarta, Founder and current CSO of Rubedo and we discuss cellular senescence, one of the most prominent causes o

The Pauling Principle Episode 26 - How do you simulate a molecule that won't sit still?

In this episode I sit down with Professor Hugo Verli, one of the pioneers in computational chemistry. And we discuss the past, present, and future of the field. Including

The Pauling Principle Episode 25 - How to design RNA (and the origin of life)

Designing functional RNA for therapeutics is notoriously hard, but gRNAde changes the game. This geometric deep learning model generates high quality RNA sequences from t

The Pauling Principle Episode 24 - Longevity with Aubrey de Grey

What if aging itself is the disease we should be curing? In this episode, I sit down with Aubrey de Grey, the legendary biogerontologist who has spent decades arguing tha

The Pauling Principle Episode 23 - Germinal and Antibody Design

Antibody design is one of the most exciting challenges in AI drug discovery. After Alphafold solved many of the problems of protein structure prediction, researchers move

The Pauling Principle Episode 21 - Reversing Reproductive Aging: Science, Not Science Fiction

In this episode, I sit down with Dr. Maria Marinova to uncover one of the most misunderstood frontiers in human biology: female reproductive aging. We break down why fema

The Pauling Principle Episode 20 - Scientific Discovery + Longevity with Matt Kaeberlein

Matt Kaeberlein is one of the world’s leading scientists in aging biology. He is a biogerontologist with 250+ publications, former University of Washington professor, and

The Pauling Principle Episode 22 - Bolz-2, Boltzgen and foundational models for molecules

Is protein folding solved? Not quite, even though the progress has been tremendous since the first AlphaFold and up to last year's Nobel prize. The team behind Boltz and

The Pauling Principle Episode 19 - Taking photos of cells with Shantanu Singh of the Broad Institute

Shantanu Singh is one of the principal investigators at the celebrated Broad Institute of MIT and Harvard. His research is centered around finding “fingerprints” of genes

The Pauling Principle Episode 18 - Can we fix mitochondria to cure Parkinson's?

Andy and his team at Vincere have been doing amazing work over years to figure out the mitochondrial mechanisms that may contribute to Parkinson's and other neurodegenera

The Pauling Principle Episode 16 - Building an AI Scientist

Andrew White and his team at Future House have one of the most ambitious missions. I'll quote here because I couldn't say it better myself: Our mission is to build an AI

The Pauling Principle - Episode 15 - Rethinking Animal Experiments with Michael Florea

What if the biggest breakthroughs in health and biotechnology aren’t waiting on new ideas but on better experiments? In this episode, Michael Florea joins Javier to expos

The Pauling Principle Episode14 - Curing cardiovascular disease to radically extend healthy lifespan

Join my conversation with Matthew "Oki" O'Connor Co-CEO of Cyclarity Therapeutics. We talk about curing cardiovascular disease, radically extending healthy longevity and

The Pauling Principle Episode 13 - Can language models understand chemistry?

Nicholas Runcie of Oxford University and I discuss whether large language models such as ChatGPT can really understand chemistry. Which of course will be essential as we

The Pauling Principle Episode 12 - The future of Computational Chemistry

Eva Smorodina, researcher at the University of Oslo and expert in Computational Chemistry, joins me for an interesting conversation about designing antibodies, tools for

The Pauling Principle Episode 11 - Curing Cardiovascular Disease

In this episode I talk with the amazing Reason and Mourad from Repair Bio about a cure for cardiovascular disease. Reason serves as CEO and is also a legend in the world

The Pauling Principle Episode 10 - The Google AI Co-Scientist

Google recently announced AI Co-Scientist, a state-of-the-art AI agent turbo-charging research. The Co-Scientist team has already uncovered new liver-fibrosis targets and