Translation

Novel Translational Therapeutics With Linda Goodman

Episode Summary:  Millions of people die every year from chronic diseases. Traditional drug discovery has failed in identifying solutions to many of these persistent hea

Building the DNA Oracle with Eeshit Vaishnav

Episode Summary The expression of genes in our genome to produce proteins and non-coding RNAs, the building blocks of life, is critical to enable life and human biology.

Demystifying Tech Transfer with Seth Bannon and Ashton Trotman-Grant

Episode Summary:   In this very special episode of Translation, Seth is joined by Ash Trotman-Grant to demystify spinning out from academia. Much of this knowledge has s

Cell Therapies of the Future with Dan Goodman

Episode Summary Chimeric antigen receptors, or CARs, repurpose the build-in targeting and homing signals of our immune system to direct T cells to find and eliminate can

DNA Origami with Anastasia Ershova

Episode Summary:  DNA is an ideal molecule for storing information in our genomes because it’s stable, programmable, and well understood. The same qualities make DNA a g

Illuminating Biological Context with Josie Kishi

Episode Summary: Technologies like next-generation sequencing allow us to understand which RNA transcripts and proteins are expressed in biological tissues. However, it’

Peering Inside the Immune Response for Novel Antibodies with Nima Emami

Episode Summary: Antibodies are one of the greatest tools we have in our therapeutic arsenal and have transformed the way we treat cancer and autoimmunity. But we still

Powering the Biocomputing Revolution with LatchBio

Episode Summary Imagine if every graphics design company built its own version of Photoshop in-house. That’s exactly what’s happening today in biology research. Ten-fold

Irresistible Cancer Therapies with Nick Goldner

Episode Summary:  Evolution is happening even at the cellular scale. Whether it's a virus, a bacterial pathogen, or a cancer cell, disease-causing agents are responding

Screening for Enhanced RNA Vaccines with Kathrin Leppek, Gun Woo Byeon, and Hannah Wayment-Steele

Episode Summary:  When COVID-19 hit and society decided to use mRNA vaccines for the first time, many questions remained about whether RNA itself was ready for the chall

Illuminating Immunity to COVID-19 with Susanna Elledge

Episode Summary: COVID-19 tests have become synonymous with jamming a swab up our nose to find out whether we have an active infection. But as we progress through this p

Listening to Neurons with Sumner Norman

Episode Summary: Brain machine interfaces untangle the complex web of neurons firing in our brains and relay the underlying meaning to a computer. These devices are bein

Phage Evolved Medicine with Travis Blum

Episode Summary: Enzymes that break down other proteins, or proteases, could be used as a powerful therapeutic if they could specifically chew-up disease causing entities

What boosts immune boosters? with Kevin Litchfield

Episode Summary:  Novel drugs that boost the immune system to fight cancer have become pharma darlings in the few short years since their approval. These drugs, known as

New CRISPR, New Function with Leo Vo

Episode Summary: In a single decade, CRISPR has made a dramatic impact on literally every facet of biotechnology. This game-changing system is traditionally programmed t

What Regulates the Regulatory T cells? with Jessica Cortez

Whether it's Multiple Sclerosis, Type 1 Diabetes, Lupus, or Crohn's Disease, autoimmunity is a rapidly growing problem that traditional pharmaceuticals have failed to com

Why CAR T Therapies are Such a Headache with Kevin Parker

Engineered T cells that hunt and kill blood cancers have recently obtained three landmark FDA approvals, forever changing the way we treat this disease. Even with its mas

Brewing a Life-Saving Drug in Yeast with Prashanth Srinivasan

Small molecules are a pillar of human health, making up a majority of the drugs we have in our healthcare arsenal. Many of these drugs are obtained by utilizing synthetic

A New Era of Antibiotic Discovery with James Martin

Bacteria are rapidly evolving ways to resist antibiotics, causing minor infections to become life-threatening events. Compounding the problem, new antibiotics have been i

Engineering the Immune System to Kill Senescent Cells with Corina Amor Vegas

Hundreds of iterations of immune cells that are engineered to kill cancer have already been designed. Corina reached outside of this box to use the same synthetic biology