The Stem Cell Report with Janet Rossant

Repair the Second Brain

The enteric nervous system (ENS) is an intricate network of neurons and glia lining the gastrointestinal tract, regulating digestion and overall health. Loss of ENS neuro

Born Without a Nose

Bosma arhinia microphthalmia syndrome (BAMS) is a rare genetic disorder resulting in babies born without a nose, along with eye and reproductive anomalies. Our guests tod

Therapeutic Strategy for COVID-19-Induced Acute Respiratory Distress Syndrome

Acute respiratory distress syndrome (ARDS) induced by COVID-19 was a leading cause of severe illness and death during the pandemic, driven by an intense innate immune res

Stem Cell-ebration: 5 Years of Breakthrough Science and Insightful Conversations

Five years ago, The Stem Cell Report set out with a simple goal: to bring the science, the people, and the stories behind stem cell research into one conversation. Since

Making Sense of Touch

Our guests today created new lab models to study Merkel cells using mouse whisker tissue cultures, mouse skin organoids, and human skin organoids. These models allowed th

Illuminating hPSC-derived Sensory Neurons

Human pluripotent stem cells (hPSCs) are transforming the study of biology and disease by enabling scientists to grow large amounts of specific cell types in the lab that

Tuning the X

Epigenetic regulation of gene expression is an important mechanism in development and disease. N6-methyladenosine (m6A) is one of the most prevalent epigenetic modificati

Building a Better Barrier: Modeling the Human Gut Epithelium

The human intestinal epithelial barrier comprises diverse proliferative, secretory and absorptive cell types that facilitate nutrient digestion and absorption and protect

Crossing the Border: Modeling the Blood Brain Barrier

The blood-brain barrier (BBB), formed by brain endothelial cells, pericytes, and astrocytes, is organized into a neurovascular unit that regulates the exchange of protein

Movin’ On Out: Mobilizing HSCs From The Bone Marrow

Hematopoietic stem cells (HSCs) normally reside in the bone marrow niche but can traffic across the bone marrow endothelium into the bloodstream to populate different nic

Cancer Neuroscience, Tumor Organoids, and Understanding the Role of the Nervous System in Human Glioblastoma

The role of neuronal influences on cancer pathogenesis and progression is increasingly appreciated in the nervous system. Neurons have been shown to enhance the prolifera

Stem Cells in Space: Muscle Regeneration in Microgravity

Skeletal muscle is one of the most abundant tissues in the human body, representing approximately 40% of body weight. Under certain circumstances, skeletal muscle can be

Parkinson's Disease, Cell Therapy, and Exercise

The potential of pluripotent stem cells and the ability to scale and differentiate them to generate large numbers of enriched cell populations has created new opportuniti

Leaving an Imprint: The Function, Impact, and Detection of Epigenetic Marks

Parent-specific epigenetic marks (imprints) leading to parent-specific gene expression are crucial for normal growth and development, yet their mechanisms of establishmen

Don’t Dull the SPARCL: The Lung Microvasculature and its Role in Development

The mature lung in both humans and mice is highly vascularized, with approximately 30% of all cells being endothelial cells (ECs). The blood vessels have a physiological

A Look Into the Future of Stem Cell Reports: A Conversation with Janet Rossant

In this special edition of the podcast, we will talk with the new Editor-in-Chief Janet Rossant and hear about her vision for the journal, its promising future, and what

SeqVerify: A New Easily Accessible Tool for Comprehensive Cell Line Quality Assessment

During the last decade, advances in genome editing and pluripotent stem cell (PSC) culture have let researchers generate edited PSC lines to study a wide variety of biolo

Guidelines for Managing and Using the Digital Phenotypes of Pluripotent Stem Cell Lines

The ability of human pluripotent and somatic stem cells to differentiate into multiple cell types of the human body makes them uniquely useful to model human development

PSC Developmental Bias: The Mechanism and the Variation in Human Neural Development

Pluripotent stem cells are defined, in part, by their potential to generate cell types from all three embryonic germ layers. However, it is well known within the field th

Aging, Stem Cells, and Biological Clocks

Epigenetic clocks based on tissue DNA methylation analysis have emerged as robust and powerful biomarkers of aging.  This technology has allowed scientists to investigate