This Week in Cardiology

Latest episodes

Showing 20 · updated from the feed

Oct 02 2026 This Week in Cardiology

Listener feedback on DANISH-CRT, the POET II trial, a mechanistic study in obesity and AF, the DANCODE trial of slowing CAC progression, and more on GLP-1 drugs are the t

Oct 2
32 min

Sep 25 2026 This Week in Cardiology

Listener feedback, pulmonary embolism intervention, simple vs complex in BiV pacing, exercise in AF, and TAVR for paradoxical low-flow, low-gradient aortic stenosis are t

Sep 25
34 min

Sep 18 2026 This Week in Cardiology

Another ESC recap, listener feedback on two trials, and a paper on GLP-1 effects on inflammation from the SELECT trial are the topics John Mandrola, MD, discusses in this

Sep 18
31 min

Sep 11 2026 This Week in Cardiology

A second ESC recap plus two breaking stories on the failure of an investigational Lp(a) reducing drug and a new FDA approval of an AI-ECG app are covered by John Mandrola

Sep 11
29 min

Sep 04 2026 This Week in Cardiology

ESC recaps on the SINGLE-AF trial, CMR Guide trial, two ATTR studies, PVI-SHAM-AF, STAREE, and an observational study of ICD benefit over the past decades are the topics

Sep 4
41 min

Aug 28 2026 This Week in Cardiology

Listener feedback on mechanical CPR devices, PFA and stroke, the Lindy effect in adopting new technology, and an ESC preview are the topics John Mandrola, MD, discusses i

Aug 28
26 min

August 21 2026 This Week in Cardiology

Mechanical CPR devices, the dangers of AF performance measures, two scholarly articles on CLOSURE and CHAMPION, and a little ESC preview are the topics John Mandrola, MD,

Aug 21
33 min

Aug 14 2026 This Week in Cardiology

Listener feedback, the ZEUS trial fails, a fascinating statin trial, more on GLP-1 drugs, and radiation safety in the EP lab are the topics John Mandrola, MD, discusses i

Aug 14
28 min

Jul 31 2026 This Week in Cardiology

Another failure of LA posterior wall isolation, first-line AF ablation, a revelation on EAST-AFNET 4 trial, an LAAC meta-analysis, and preventing AKI post-cardiac surgery

Jul 31
31 min

July 24 2026 This Week in Cardiology

The first oral PCSK9 inhibitor, another study finding safe MRI scanning in patients with nonconditional CIEDs, the PFA-SHAM trial, and the curious case of orthopedic inju

Jul 24
25 min

Jul 17 2026 This Week in Cardiology Podcast

DAPT back in the news, a practice-changing trial in VTE therapy, new knowledge in sudden cardiac death, heart failure definitions updated, and a dumb decision by NICE in

Jul 17
34 min

Jul 10 2026 This Week in Cardiology

Listener feedback on ICE vs TEE in AF ablation, fractional flow reserve without a wire or catheter, more bad news for ticagrelor, the POLY-HF trial, and oxygen targets af

Jul 10
31 min

Jun 26 2026 This Week in Cardiology

Listener feedback on valvular heart disease, statins and frailty, left atrial posterior wall ablation fails again, interpreting medical tests and AI ECG reading are the t

Jun 26
33 min

Jun 19 2026 This Week in Cardiology

Listener feedback, more long-term data on the TAVR/SAVR question, population prevalence of valvular heart disease in the US, and a CMS proposal to expand TAVR coverage ar

Jun 19
36 min

Jun 12 2026 This Week in Cardiology

Listener feedback, transcatheter tricuspid valve replacement, a new metabolic disease called CKM, the ARISE-FLUIDS Trial, the BIHCA trial, and temporal trends in ICD ther

Jun 12
30 min

Jun 05 2026 This Week in Cardiology

Chemical cardioversion in the ED, HF monitoring, weight loss in AF, and surgical LAA excision are the topics John Mandrola, MD, discusses in this week's podcast. This p

Jun 5
31 min

May 29 2026 This Week in Cardiology

A life-long treatment for high LDL, a VESALIUS subanalysis, tirzepatide beats semaglutide again, arrhythmia burden in cardiac amyloidosis, and a lipid guideline rebuttal

May 29
28 min

May 22 2026 This Week in Cardiology

Three more digoxin trials, yet another GLP-1 drug on the horizon, vagal nerve stimulation, trial inside baseball, and more on lipid guidelines are the topics John Mandrol

May 22
32 min

May 15, 2026 This Week in Cardiology

Another positive digoxin trial, another classic coronary physiology study from Imperial College London (ORBITA-FIRE), news in hypertrophic cardiomyopathy, and TAVR done i

May 15
31 min

May 08 2026 This Week in Cardiology

Listener feedback from the DanGer Shock investigators, complete vs staged revascularization, polygenic risk scores, and quality improvement failure in an RCT are the topi

May 8
29 min

Chart trend

Position in the Science chart (US), last 90 days.

#1#84#167JulAugSepOct

#26

all-time peak

days in the top 50 since Nov 2024

Chart positions

Where This Week in Cardiology ranks today in each Apple Podcasts chart (US, Oct 6, 2026).

#88 ▲ 5 Science US

What listeners say

A curated, balanced selection of Apple Podcasts reviews.

It has become a weekly ritual for me—and for many of the cardiologists in my practice—to listen to Dr. John Mandrola’s This Week in Cardiology every Friday afternoon. Dr. Mandrola provides a thoughtful, critical appraisal of the latest clinical trials that often goes far beyond the enthusiastic interpretations frequently seen in journals, press releases, and social media. He is admittedly a bit of a curmudgeon and, at times, displays some bias against certain therapies (LAAO, ARNIs, FFR-CT, and TAVR in low-risk patients) while showing perhaps a bit too much enthusiasm for others (PFA). That said, he is consistently thought-provoking, intellectually honest, and informative. I am a better cardiologist because of what I’ve learned from his podcast. Thank you, Dr. Mandrola.

skalathi · Aug 2026

This podcast is perfect for a trainee. I just finished residency and chief year; I find this podcast digestible with the right mix of clear breakdowns of trials and statistics within them with the sort of folksy advice and soapboxes you want from an attending. I am genuinely developing a sense of good and bad trials and approaches to clinical medicine. This is not milquetoast, this is a real doctor teaching.

Stein Entered the Chat · Aug 2026

Dr. Mandrola is an excellent speaker and brings important information from current trials. I love his “but…but” comments—it’s always a clue to listen more closely as an astute observation is about to be shared.

djwits · Jul 2026

Love this podcast. Dr Mandrola reviews the most important cardiology trials every week and adds his commentary that are very insighful. Easy way to keep up with the ever changing field of cardiology.

Appyton · May 2026

We strive to present a balanced view by showing a diverse range of reviews from Apple Podcasts.