The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!
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Latest episodes
Showing 20 · updated from the feed
How AI Is Rewriting the Power Law of Venture Capital
#33 trending · Technology
a16z’s Jen Kha and David George sit down with Accolade Partners’ Aram Verdiyan to discuss how AI is changing the power law of technology investing, why the largest compan
Sep 10 49 min
Who Grades the AI Models? | Ben Horowitz & Rayan Krishnan
#37 trending · Technology
a16z’s Erik Torenberg, Ben Horowitz, and Jennifer Li sit down with Vals founder and CEO Rayan Krishnan to discuss one of AI’s increasingly difficult problems: how do you
Sep 9 39 min
OpenAI Researchers on the Future of Mathematical Reasoning
a16z Infra Partner Lisha Li sits down with OpenAI mathematicians Mehtaab Sawhney and Mark Sellke to discuss how quickly AI’s mathematical capabilities are advancing, what
Sep 8 1 h 05 min
Can Open Source Keep AI Power From Concentrating?
MTS host Sophia Dew visits the Open Source AI Summit in San Francisco to ask researchers and founders across the AI stack a central question: can open source prevent AI p
Sep 7 8 min
Your AI Doctor Is Coming | Julie Yoo
a16z General Partner Julie Yoo joins MTS host Sophia Dew to explain why she believes healthcare could benefit more from AI than almost any other industry, and why decades
Sep 6 27 min
Aaron Levie on Why Open AI Wins
Box co-founder and CEO Aaron Levie joins MTS hosts Theo Jaffee and Sofia Puccini to make the case for open-weight AI, unpack the economics of open versus closed models, a
Sep 5 31 min
Fei Fei Li: The Race to Build World Models For AI
World Labs co-founders Fei-Fei Li, Justin Johnson, and Ben Mildenhall join a16z General Partner Martin Casado to discuss Atlas, their latest world model, and what it reve
Sep 4 44 min
The $100B Niches Hiding Inside Payments
Erik Torenberg is joined by a16z General Partner Alex Rampell and Affirm Co-Founder and CEO Max Levchin for a conversation on 25 years of fintech, from the early days of
Sep 3 1 h 00 min
Inside Moderna’s Personalized Cancer Vaccine
a16z General Partner Jorge Conde sits down with Moderna CEO Stéphane Bancel to discuss a major milestone for mRNA technology: positive Phase 3 results from Moderna and Me
Sep 2 40 min
Daniel Litt: The Mathematician's Guide to AI
a16z’s Lisha Li sits down with Daniel Litt, Assistant Professor of Mathematics at the University of Toronto, to unpack AI's rapid progress in mathematics, what today's fr
Sep 1 1 h 03 min
Gavin Baker: Why AI Demand Is Outrunning Compute Supply
a16z’s David George sits down with Gavin Baker to unpack the state of the AI boom, why demand for intelligence may still be dramatically underestimated, and why the outco
Aug 31 1 h 15 min
Why a16z Launched the Machine Age Fund | Jen Kha
a16z Managing Partner and Head of Global Partnerships Jen Kha joins MTS hosts Theo Jaffee and Sophia Dew to discuss a16z's Machine Age Fund and the investment thesis behi
Aug 30 24 min
Why 1,200 AI Agents Started Working Together | Ryan Greenblatt
Ryan Greenblatt, Chief Scientist at Redwood Research, joins MTS host Theo Jaffee to unpack a new independent investigation into the OpenAI Hugging Face hacking incident a
Aug 29 34 min
The Infrastructure Behind the Machine Age
Ben Horowitz, Martin Casado, Raghu Raghuram, and Erik Torenberg discuss the launch of a16z's new Machine Age Fund and the infrastructure buildout behind AI, from chips, m
Aug 28 55 min
Inside Cursor: The Anatomy of a Generational Startup
a16z General Partners Martin Casado, Sarah Wang, and Matt Bornstein unpack the story of Cursor: how a small, product-obsessed team entered one of the most competitive mar
Aug 27 39 min
The State of AI: Macro, Apps, and Consumer
Anish Acharya joins Jen Kha to break down the next frontier of AI, from the evolving model landscape and open-source AI to why the application layer, and consumer AI in p
Aug 26 37 min
The New Economics of AI | Martin Casado & Steven Sinofsky
a16z General Partners Martin Casado and Erik Torenberg are joined by Board Partner Steven Sinofsky to explore what recent breakthroughs in AI and mathematics tell us abou
Aug 25 1 h 03 min
Why Medical AI Needs a Referee | Protege's Engy Ziedan
Daisy Wolf and Eva Steinman are joined by Engy Ziedan, co-founder and Chief Scientific Officer of Protege, to discuss why medical AI has a measurement problem, and why sc
Aug 24 35 min
Martin Casado on Where the Value Is Going in AI
Martin Casado joins MTS hosts Theo Jaffee and Sophia Dew to unpack where value is actually accruing in AI, why this technology cycle looks fundamentally different from pr
Aug 22 42 min
Microsoft's Deputy CISO on Securing AI Agents
a16z's Joel De La Garza is joined by Aaron Zollman, Deputy CISO at Microsoft Gaming, to discuss how security teams can embrace AI agents without losing control.
Aaron sh
Aug 21 25 min
Chart positions
Where The a16z Show ranks today in each Apple Podcasts chart (US, Sep 10, 2026).
A curated, balanced selection of Apple Podcasts reviews.
Consistently impactful topics. Provocative policy discussion distinguishing a health focus from disease focus where the former offers sustainable solutions.
[ lblank ] · Nov 2024
This podcast is a must-listen for its insightful discussions at the crossroads of technology, business, and culture. Steph is a super engaging host, and they have a diverse range of industry expert guests that make complex topics accessible and fascinating for all.
Rios111 · Jan 2024
Enjoy many episodes and range of topics, speakers and perspectives shared. Good mix of tech , impact and eye on future! Also enjoy hear the founders on some shows
SRam5 · Nov 2023
Excellent interview with Joon Park, thank you, your team at a16z is setting up a very important link between human behavior and generative AI, digital/interpretive behavioral modeling and other types of large language processing designs to close the gap between the vast complexity of neurobiological processes that leads to specific behavioral expressions and codifying and encapsulating that in a generative AI system, looking forward to more of those types of episodes that also address specific behavior such as violence and anger and aggression to highlight research teams around the world working on better understanding of how to intervene and treat aggressive behavior in order to create more peaceful individual and societal behavior.
Sheldon1818 · Nov 2023
A16Z often has great tech related guests and fairly good interviewers, but sometimes the audio quality is horrible. For example, the recent Balaji episode from April 22nd is unlistenable.
Alex kahn · Apr 2026
Used to be a great podcast for insights on innovation, holistic disruptive thinking, and actual innovation. After a number of departures 2 or so years ago, everything has gone sideways. Has gone from a must listen to actively being counter productive to listen to. Such a shame. And such a waste that they’ve gone so far off the rails.
StudytheWorld · Jul 2024
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