Latent Space: The AI Engineer Podcast

You are the Team — Anekha Sokhal, Moshi

Anekha Sokhal, CEO of Moshi, joins swyx to discuss building a recommendation engine for commodity traders, turning market data into useful signals, and designing AI that

AI for the Fortune 2000: How Tenex Builds an AI-Native SDLC — Alex Lieberman & CJ Hess

Alex Lieberman and CJ Hess join swyx at AI Engineer New York to discuss Tenex’s approach to AI-native engineering, paying for outcomes, MetaHarness, enterprise AI adoptio

The Programmable Data Center — Evan Conrad, SF Compute

This was recorded on the sidelines of the new Compute Trading track at AIE NYC. Catch us next at AIE CODE, our last flagship for the top agentic engineers in the world.

Lab-in-the-Loop at Compute Speed — Ian Quigley, Leash Bio

A few years ago I stumbled upon Leash Bio’s Substack, and was hooked. Be it their Kaggle competition that showed that no, we really haven’t solved protein-ligand binding,

Dyna-2: General Purpose Physical Agents with Hour-Long Autonomy — Jason Ma, Dyna Robotics

Watch along AIE NYC and join us at AIE CODE in SF next month! This episode includes a live demo of the Taku robot that is best enjoyed on YouTube. Last month, Dyna made

Why AlphaFold Didn't Solve Protein Folding — Pushmeet Kohli, Google DeepMind & Sal Candido, Biohub

From the Bitter Lesson of AI scaling to the unsolved mysteries of protein folding, Google DeepMind’s Pushmeet Kohli and Biohub’s Sal Candido are rethinking what it takes

Synthesis Superintelligence: from Semiconductors to Superconductors — Periodic Labs’ Liam Fedus and Ekin Dogus Cubuk

It’s hard to believe that Periodic was only launched last September: One year later, it is considered one of the pre-eminent AI scientist labs, with dizzying talent dens

Academia is for Ambition — Alex Zhang, MIT

Last call for regular tickets for AI Engineer NYC! As an exclusive for Latent Space subscribers, the first 30 of you can take a 30% off code if it helps - for new tickets

Why Dwarkesh is Wrong about Computer Use + How OpenAI shipped its Jev competitor in 1 Week

Three months ago Dwarkesh, who has been posting incredible blogs and episodes about RL, posted a framing question for his video essay on RLVR which upset a lot of Compute

Claude Code’s Next Era — Thariq Shihipar, Anthropic

We are excited to have Anthropic share their latest AI x Finance work at AI Engineer New York, coming up in 2 weeks! In case you’ve been under a rock, here’s a non-exhau

OpenRouter: from Seed to Stripe — with OpenRouter’s Alex Atallah & AMP’s Anjney Midha

From the earliest days of open-weight models to becoming the neutral routing layer for more than 10 million developers, OpenRouter is one of the clearest bets that the fu

Runway’s WorldPrompt and the Engineering of Real-Time Worlds

Earlier this month, world model company Runway introduced GWM Worlds 2, a research preview that “turns high-fidelity video and audio generation into real-time interactive

🔬Bio-security is an AI Arms Race - Eric Nguyen (CEO, Radical Numerics)

The OpenAI → Hugging Face attack has people asking “what else do we need to worry about?” and Anthropic’s filters flag two things: cyber-security and biology. The natural

🔬 An Oscar, Two Asteroids, and the Algorithm in Your sklearn: John Platt on AI for Science

How often do you get to talk to a guest who has both an Academy Award and who invented textbook machine learning algorithms? John Platt has an Oscar, two textbook algorit

Jev: System One models for Prod, not God — with Diogo Almeida, CEO, TypeSafe AI

Tickets for AIE NYC now open, and apply for the invite-only AIE CODE. Join us! We have an unusual relationship with today’s guest: for years since coauthoring the Instru

Underwriting Superintelligence: Backing Agents you can Sue — Rune Kvist, AIUC

AIUC first got our attention with the NFDG backing, and have just announced a $40M series A today, with the most impressive industry advisor list we may have ever seen fo

Humanity’s Last Invention — Richard Socher of Recursive

At 1:09:00 we talk about the rise of AI x Finance, and AIE NYC is one month away - our hotel block is 97% sold out, get tix & travel ASAP - we will announce speakers from

🔬“We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing

A few years ago, Caltech Prof. and co-founder of Accelerated Understanding, Anima Anandkumar set out to develop the first open-source weather model with AI. Talking to ex

Simulation: the new Scaling Law — Joon Sung Park, Simile AI

When we first dicsussed the Summer of Simulative AI in 2024 we knew it would be a brief summer, but it has recently come back with a vengeance with SimGym in April and no

🔬The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery

This January, four big AI × Pharma tools deals were announced at the huge JPM Pharma conference that takes over San Francisco every year. OpenAI-backed Chai Discovery (no