Joe Lonsdale: American Optimist

Ep 161: Generalist CEO Pete Florence on the Robot Revolution & Bringing General Intelligence to the Physical World

Until recently, robots were constrained to narrow, specific tasks. Think assembly lines, medical devices, or household vacuum cleaners. But now all that is changing. One

Ep 160: Box CEO Aaron Levie on Silicon Valley's AI Problem, Evidence for AI Job Creation & What Doomers and Accelerationists Get Wrong

Aaron Levie has spent two decades building Box into a cloud storage leader — and he's never been more excited for the future. What's next in the AI wave? Where is he alre

Ep 159: Aaron Cannon Is Building the Leading AI Customer Research Platform; It's About to Upend a $140B Industry

Aaron Cannon is applying AI to solve one of the oldest and most important challenges in business: understanding exactly what customers want and need. Traditional consumer

Ep 158: Nima Ghamsari on Blend's Comeback & the Power of AI Agents and Infinite Workforce

Nima Ghamsari was a top talent at Palantir before founding Blend Labs to digitize the mortgage process. Blend became one of Silicon Valley’s hottest SaaS companies until

Ep 157: Scott Nolan on the AI Energy Crisis & America's Nuclear Renaissance

In 2010, the U.S. and China were at parity in electricity generation. Today, China boasts triple our capacity. We’re at the vanguard of the AI revolution but falling dang

Ep 156: Coleman Hughes Takes on America's Most Contentious Debate: the Legacy of Slavery

Is America’s national wealth built on slavery? Are disparities between races today attributable to past injustices? Will we ever overcome race politics? These difficult q

Ep 155: Eric Scott on the Biggest Missed Opportunity in Venture Investing

As a former Principal at Founders Fund, Founding Partner at SciFi VC, and 8VC advisor, Eric Scott has invested in and helped build numerous technology leaders. He’s launc

Ep 154: Jacob Helberg on Pax Silica & the New Global Order in the AI Age

Jacob Helberg is leading the State Department's efforts to secure critical supply chains and win the global AI race. How is the U.S. shifting from dependency on China to

Ep 153: Palantir CTO Shyam Sankar on Heretics, AI Weapons, and Rebuilding the Arsenal of Democracy

Shyam Sankar is one of my favorite American innovators. As CTO of Palantir, he's been a key leader for over 20 years and built much of what the company stands for. He's a

Ep 152: Ben Black Runs America's $200B Foreign Investment Fund; Here's His Plan to Counter China & Rebuild American Influence

Ben Black is the CEO of the U.S. International Development Finance Corporation (DFC). Backed by a $205 billion budget, his mandate is to invest in U.S. strategic interest

Ep 151: The Myth of Michael Milken with Richard Sandler

Michael Milken revolutionized American finance and democratized access to capital for thousands of companies that Wall Street had previously written off. Yet he was unjus

Ep 150: How AI Is Transforming Diligence, Decision-Making & the Future of Investing with John Melas-Kyriazi

John Melas-Kyriazi is the co-founder and CEO of Standard Metrics, which powers portfolio management for more than 150 venture capital firms and 10,000 companies. He runs

Ep 149: Will Fry on the Small Business Succession Crisis & New Opportunities in the AI Age

In the coming years, over two million small businesses will change hands or close their doors as Baby Boomers retire. Will Fry, Founder and CEO of American Operator, is o

Ep 148: JoeBen Bevirt, Founder & CEO of Joby Aviation — Flying Cars Have Arrived

Last year, JoeBen Bevirt joined the show to discuss the vision behind Joby Aviation and bringing air taxis to life. Now, he's back to talk execution and getting to market

Ep 147: Scott Wu & Russell Kaplan on the New Era of Software Abundance

Scott Wu and Russell Kaplan, co-founders of Cognition, are leading one of the fastest-growing, talent-dense AI companies. Their mission: make expert software engineering

Ep 146: Jake Paul & Geoff Woo on Building Anti Fund, the Future of the Creator Economy & How to Change the Culture

Jake Paul is a social media influencer-turned-entrepreneur and boxer. He’s not only one of the most popular figures on the planet among Gen Z, but also an outspoken patri

Ep 145: SBA Administrator Kelly Loeffler on Exposing Billions in Fraud & What AI Means for Small Business

Small Business Administrator Kelly Loeffler is playing a pivotal role in our nation on two fronts: supporting the next generation of small business owners, while exposing

Ep 144: Jared Isaacman's Bold Vision for Moon Bases, Nuclear Power in Space, and Returning NASA to Greatness

As a teenager, Jared Isaacman built a billion-dollar payments company. He then pursued aviation, acquiring the world's largest private air force and creating “Top Gun as

Ep 143: JD Ross on the New Invention Era & Building with AI in 2026

JD Ross is one of my favorite entrepreneurs. I hired him out of college at Addepar where he quickly became Head of Product. He went on to co-found Opendoor with Keith Rab

Ep 142: Understanding the AI Wave with 8VC's Alex Kolicich & Jack Moshkovich

Advances in AI are occurring at a pace we haven’t seen before in Silicon Valley. How do we know what’s real versus hype? What does it mean for large software incumbents?