Symptomatic: A Medical Mystery Podcast artwork

Documentary · iHeartPodcasts

Symptomatic: A Medical Mystery Podcast

by iHeartPodcasts

How terrifying would it be to fight an unknown enemy? One you don’t recognize and didn’t see coming? What if that enemy was coming from within; a disease that even doctors couldn’t identify? Nearly half of all Americans suffer from some chronic illness and many struggle for an accurate diagnosis. Every other week on Symptomatic, host Lauren Bright Pacheco unravels the medical mystery of a patient’s baffling symptoms and explores how their lives were turned upside down in search of answers.  From the first signs of trouble, through a swirl of misdirection and failed treatment attempts, to the final relief at a confirmed diagnosis - these are their stories. This is Symptomatic. We want to hear from you! Tell us what you think of the show or share your own medical mystery by emailing us at Symptomatic@iHeartMedia.com.

Latest episodes

Showing 20 · updated from the feed

Case #38: Heather

#14 trending · Documentary

Out of nowhere, Heather Bardeleben felt a jolt in her chest. She spends the next 12 hours in excruciating pain, suffering through what feels like a vice clamping down on

Nov 3
48 min

Case #37: Grace

Grace Sullivan was only 17 when she was hit by unexplained bouts of uncontrollable vomiting that would last for days, even weeks. Countless trips to the ER, tests with no

Oct 27
49 min

Case #36: Travis

Travis Bolt was a charismatic kid with an old soul…and a natural talent for music. When Travis turns eight years old, he begins to experience uncontrollable muscle moveme

Oct 20
50 min

Case #03: Zach - Revisited

Let's revisit one of our favorite episodes from Season 1. Zach was your average 11-year-old who loved pizza, sports, and going fishing with his Dad until an incident at a

Oct 15
33 min

Case #35: Len (Pt. 2)

This is part two of Len Geiger’s story. The last we heard from Len, he was flying over the handlebars of his mountain bike only three months after receiving a miraculous

Oct 6
38 min

Case #35: Len

Len Geiger was a perfectly healthy, athletic young man with no signs of illness…but when Len enters his late twenties he starts falling ill with chronic chest infections.

Sep 29
47 min

Case #34: Brendon

Brendon Paradis began to lose his vision out of nowhere. Doctors spend decades trying to stop the unexplained hemorrhaging in his retina with no success. Brendon has atte

Sep 22
49 min

Symptomatic is back with Season 5!

All new episodes full of medical mysteries are coming soon. Join host Lauren Bright Pacheco as we explore new stories in which patients become investigators, survivors be

Sep 15
2 min

Case #33: Phoebe

Sarah Marshall knew from only a few months into her fourth daughter Phoebe's life that something was definitely wrong. By the time Phoebe was six, Sarah began to fear for

Dec 23 2025
41 min

Case #32: Michelle

Michelle Shapiro had built a career helping others get healthy when she was hit with a debilitating health crisis. Doctors were unable to identify the cause of her sympto

Dec 16 2025
38 min

Case #31: Kristen

What began as intermittent rashes that popped up years apart turned into excruciating, long term flare ups with no reprieve for Kristen Willard. Unable to sleep, shower,

Dec 9 2025
43 min

Case #30: Rose & Casey

Rockstar Casey McPherson and his family were shocked to the core when his daughter Rose was diagnosed with a rare genetic mutation that has no known treatment. Faced with

Dec 2 2025
40 min

Case #29: Cienna

For as long as Cienna Ditri can remember, she has had random bouts of “heavy legs”and loss of vision. As she got older - that sensation grew into episodes in which she co

Nov 25 2025
41 min

Case #28: Ian

Ian Stedman suffered 32 years with full body rashes, debilitating headaches, joint pain and hearing loss without a clear diagnosis. His Mother Barb had gone over 60 years

Nov 18 2025
47 min

Case #27: Hailey

From the moment Hailey got her period, she could tell that something was different about her. Suffering debilitating menstrual cramps and a flow so heavy she would pass o

Nov 11 2025
42 min

Case #26: Nika

Nika spent half her life battling a shape-shifting condition that plagued her in various ways for nearly two decades. Fighting chronic pain, fevers, fatigue, and even str

Nov 4 2025
39 min

Symptomatic Returns!

New season. New mysteries. Host Lauren Bright Pacheco returns to uncover the hidden truths behind chronic and rare illnesses. These are the stories of symptoms that defy

Oct 28 2025
2 min

A Special Re-Release: Case #17: Every Cure Pt.1 (Dr. David Fajgenbaum)

We’re celebrating Dr. David Fajgenbaum and revisiting one of our most impactful stories. David was just named to the TIME100 Health list and has a powerful new TED Talk—m

Sep 9 2025
42 min

Case #25: Trent (Pt. 2)

Just when Trent starts to believe the worst is behind him, an unexpected twist turns his world upside down. He’s forced to confront new challenges that test his resilienc

Dec 24 2024
32 min

Case #25: Trent (Pt. 1)

Trent was a vibrant and successful insurance assessor when his life took an unexpected turn. While working under a car, he sensed something was off. It wasn’t until later

Dec 17 2024
28 min

Chart trend

Position in the Documentary chart (US), last 90 days.

#2
all-time peak
3
days in the top 3 since Nov 2024

Chart positions

Where Symptomatic: A Medical Mystery Podcast ranks today in each Apple Podcasts chart (US, Nov 5, 2026).

#36 ▲ 3 Documentary US

What listeners say

A curated, balanced selection of Apple Podcasts reviews.

This is an amazing podcast. The combination of interviews, narration and just enough science keep me glued! I am a nurse and normally I would not want to listen to “medical” podcasts on my time off. This is different. These are stories about real people. I am feeling every emotion from confusion when they don’t understand what is happening with their bodies, fear, and relief when finally being diagnosed. It is a wild tide and I am here for it!

12282021 · Oct 2026

I love the mix of science and humanity. Beautiful storytelling, interviews and editing. This podcast is a true delight!

Texas House Call Veterinarian · Sep 2026

I love this show! The way Denver cracks Teresa up: relationship goals. And to the haters leaving 1 star reviews because of the banter? That’s a YOU problem, not a content problem. Are these two experts on everything? Nope. Refreshingly relatable, not know-it-alls.

silkiestpaper · Aug 2026

Newer listener so I was able to back to the 1st then begin my journey. I absolutely love the education part. I have no medical issue, thank goodness, but this is something that people can listen to and recognize their own issues or know someone going through similar issues. You do have to be your own advocate these days. The podcast helps so much, hearing these crazy journeys that humans have to go through before they find that “right” Doctor! Amazing Doctors out there, unfortunately, you have to find them!!

Duckpkh2015 · Mar 2026

I thought I would like this podcast, but it feels so overproduced and contrived. Music is fine on a podcast, but the music they chose is way over the top and too loud in relation to the person’s voice, I agree very much with the person that said this podcast has a lifetime movie type feel and it’s not a compliment. I could over look the music if the content was interesting or compelling, but it’s rather dull and the repetitiveness of how painful it was and how much the person persevered makes it boring and redundant, plus there’s not a whole lot in the way of explaining the medical side of conditions, diseases, etc. I’d skip it unless you like lame and cheesy, emotionally manipulative lifetime movies, but it’s a hard pass for me.

mdl6841 · Mar 2024

I see the goal of this podcast, but not enough pertinent, information is given in the episodes. For example, Hailey went almost 10 years with her debilitating symptoms, and there’s no information given on in that time frame on- did she see a primary care provider and explain her symptoms and if so, did that primary care provider refer her to an OB/GYN? Her symptoms are definitely not normal, so hard to believe that in that timeframe, she never got referred to an OB/GYN and an ultrasound was not ordered. An ultrasound is inexpensive and a non-invasive, which is probably one of the first things to order in a female with her symptoms.

PSSP25 · Jan 2026

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