Symptomatic: A Medical Mystery Podcast artwork

Documentary · iHeartPodcasts

Symptomatic: A Medical Mystery Podcast

by iHeartPodcasts

How terrifying would it be to fight an unknown enemy? One you don’t recognize and didn’t see coming? What if that enemy was coming from within; a disease that even doctors couldn’t identify? Nearly half of all Americans suffer from some chronic illness and many struggle for an accurate diagnosis. Every other week on Symptomatic, host Lauren Bright Pacheco unravels the medical mystery of a patient’s baffling symptoms and explores how their lives were turned upside down in search of answers.  From the first signs of trouble, through a swirl of misdirection and failed treatment attempts, to the final relief at a confirmed diagnosis - these are their stories. This is Symptomatic. We want to hear from you! Tell us what you think of the show or share your own medical mystery by emailing us at Symptomatic@iHeartMedia.com.

Chart trend

Position in the Documentary chart (US), last 90 days.

#11
all-time peak
134
days in the top 50 since Nov 2024

Latest episodes

Showing 20 · updated from the feed

Case #33: Phoebe

Sarah Marshall knew from only a few months into her fourth daughter Phoebe's life that something was definitely wrong. By the time Phoebe was six, Sarah began to fear for

Dec 23 2025
41 min

Case #32: Michelle

Michelle Shapiro had built a career helping others get healthy when she was hit with a debilitating health crisis. Doctors were unable to identify the cause of her sympto

Dec 16 2025
38 min

Case #31: Kristen

What began as intermittent rashes that popped up years apart turned into excruciating, long term flare ups with no reprieve for Kristen Willard. Unable to sleep, shower,

Dec 9 2025
43 min

Case #30: Rose & Casey

Rockstar Casey McPherson and his family were shocked to the core when his daughter Rose was diagnosed with a rare genetic mutation that has no known treatment. Faced with

Dec 2 2025
40 min

Case #29: Cienna

For as long as Cienna Ditri can remember, she has had random bouts of “heavy legs”and loss of vision. As she got older - that sensation grew into episodes in which she co

Nov 25 2025
41 min

Case #28: Ian

Ian Stedman suffered 32 years with full body rashes, debilitating headaches, joint pain and hearing loss without a clear diagnosis. His Mother Barb had gone over 60 years

Nov 18 2025
47 min

Case #27: Hailey

From the moment Hailey got her period, she could tell that something was different about her. Suffering debilitating menstrual cramps and a flow so heavy she would pass o

Nov 11 2025
42 min

Case #26: Nika

Nika spent half her life battling a shape-shifting condition that plagued her in various ways for nearly two decades. Fighting chronic pain, fevers, fatigue, and even str

Nov 4 2025
39 min

Symptomatic Returns!

New season. New mysteries. Host Lauren Bright Pacheco returns to uncover the hidden truths behind chronic and rare illnesses. These are the stories of symptoms that defy

Oct 28 2025
2 min

A Special Re-Release: Case #17: Every Cure Pt.1 (Dr. David Fajgenbaum)

We’re celebrating Dr. David Fajgenbaum and revisiting one of our most impactful stories. David was just named to the TIME100 Health list and has a powerful new TED Talk—m

Sep 9 2025
42 min

Case #25: Trent (Pt. 2)

Just when Trent starts to believe the worst is behind him, an unexpected twist turns his world upside down. He’s forced to confront new challenges that test his resilienc

Dec 24 2024
32 min

Case #25: Trent (Pt. 1)

Trent was a vibrant and successful insurance assessor when his life took an unexpected turn. While working under a car, he sensed something was off. It wasn’t until later

Dec 17 2024
28 min

House Calls - Case #16: Lauren

In this next installment of Symptomatic: House Calls, we check in on Lauren from Case #16. Lauren began noticing severe pain that could not be explained away by her pro

Dec 10 2024
16 min

Case #24: Sumaira

When Sumaira was 24, what seemed like a routine wisdom teeth extraction quickly set off a series of unexpected health issues. Soon after, her vision in her right eye bega

Dec 3 2024
43 min

Case #23: Mik

Mik’s health challenges began at an early age, with unusual symptoms like recurring staph infections from small cuts—signs that both doctors and her family brushed aside.

Nov 26 2024
40 min

House Calls - Case #13: Alisha

In this next installment of Symptomatic: House Calls, we catch up with Alisha from Case #13. Spoiler Alert: If you haven’t listened to this episode yet, you might want

Nov 19 2024
16 min

Case #22: Mila

In her mid-20s and thriving in a fast-paced communications job, Mila began experiencing symptoms reminiscent of those her mom had managed with diabetes for years. However

Nov 12 2024
39 min

Case #21: Scott

In peak health, Scott's life took a drastic turn when a rare disease nearly claimed it all. Initially misdiagnosed and dismissed, his symptoms escalated into a near-fatal

Nov 5 2024
38 min

House Calls - Case #02: Athena

In this bonus episode, we introduce Symptomatic: House Calls. Throughout Season 3, we will reconnect with past guests to get updates on how they’ve been managing their co

Oct 29 2024
18 min

Case #20: Kelly

In her early 30s, Kelly was suddenly plagued by a series of inexplicable health issues, from severe heartburn to rapid weight gain, leaving doctors utterly baffled. Misdi

Oct 22 2024
36 min

Chart positions

Where Symptomatic: A Medical Mystery Podcast ranks today in each Apple Podcasts chart (US, Sep 4, 2026).

#112 Documentary US

What listeners say

A curated, balanced selection of Apple Podcasts reviews.

It’s a well done show and thorough. However it is billed as science based medical mystery when in reality it’s more of a talk show dealing with feelings and emotions of the subjects instead of the science and intrigue. If you are in to Lifetime network more than Discovery Channel, check it out, but if you want true medical mystery, look elsewhere.

H Charles · Oct 2024

How lucky the vast majority of us are to wake each day with a healthy body. This podcast will make you grateful for your own good health and open your eyes to the many mysterious ways your body can fail you. Moreover, it will introduce you to the strong men and women who suffer from these maladies and to those who dedicate their lives to finding a solution.

Tangle70 · Aug 2024

As a veterinarian and someone who has battled a chronic illness, I have always enjoyed medical mystery shows, podcasts, etc. I liked the show immediately, but when I listened to the fourth episode about Shelby’s story, my jaw was on the floor. She was literally describing my exact experience with debilitating chronic fatigue (even down to the same initial “trigger”). I had pursued a diagnosis for years, but after normal blood tests, inconclusive sleep studies, and countless doctors telling me that my symptoms were “probably psychological,” I felt hopeless and thought that I was destined to be exhausted for the rest of my life. While I am still waiting for an official diagnosis, implementing the basic non-pharmaceutical treatments for POTS (increasing salt/water intake, using compression stockings, etc.) has helped me so much that I was able to stop taking prescription stimulants to stay awake. While I obviously relate very personally to this particular episode, every episode does a great job of conveying the seriousness of the medical ailment while still maintaining a sense of hope and positivity for other individuals battling with similar symptoms.

PetVet13 · Jul 2024

I love these types of documentary style podcasts but find it frustrating when they’re not updated regularly without explanation. I hope more episodes are coming soon. This is one I would definitely continue listening to. Very interesting and love the host’s voice.

AngryEbayer · Jan 2024

I thought I would like this podcast, but it feels so overproduced and contrived. Music is fine on a podcast, but the music they chose is way over the top and too loud in relation to the person’s voice, I agree very much with the person that said this podcast has a lifetime movie type feel and it’s not a compliment. I could over look the music if the content was interesting or compelling, but it’s rather dull and the repetitiveness of how painful it was and how much the person persevered makes it boring and redundant, plus there’s not a whole lot in the way of explaining the medical side of conditions, diseases, etc. I’d skip it unless you like lame and cheesy, emotionally manipulative lifetime movies, but it’s a hard pass for me.

mdl6841 · Mar 2024

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