Mendelspod Podcast

The UK’s Next Big Bet on Precision Medicine: Our Future Health with CEO Raghib Ali

In the US, we have the All of Us Research Program. In the UK, they have Our Future Health, an ambitious new population health research program that aims to make healthcar

From the Archives: The Dark Genome Is Coming Into Focus with Sudhakaran Prabakaran

In recent months on Mendelspod, we’ve explored how new sequencing and proteomics technologies are revealing biology in regions of the genome (and proteome) that have long

Repeat Expansions and the Promise of Long Reads with Alex Lindell and Simon Sadedin

Repeat expansions are places where the genome has remained stubbornly dark. Long-read sequencing is beginning to illuminate them, and now that new visibility is moving in

How Roswell Park Is Rethinking Molecular Testing for Blood Cancers with Sean Glenn

Sometimes the best evidence that a new medical technology is working is simply that doctors start depending on it. For years, the promise of molecular medicine has been t

Building a Single Cell Atlas of the Poplar Tree with Robin Buell and Anita Giabardo

Plant biology too is benefiting from single cell resolution. Unlike animals, plants cannot move away from environmental stress. They have evolved tremendous biological c

Three Illumina 5-Base Grant Contest Winners Share Cancer Research Insights from Combining Epigenetics and Genetics

What new insights can we learn about cancer when researchers are able to look at the genome and the methylome together? Recently, Illumina launched its 5-base for Cancer

Ten Years Ago Mike Joyner Was Skeptical of Precision Medicine. What Does He Say Today?

This is a free preview of a paid episode. To hear more, visit www.mendelspod.com A recent New York Times article highlighted a remarkable study showing that exercise can

Deeper into the Genome: Google DeepMind’s Ziga Avsec on the New AlphaGenome Atlas

This is a free preview of a paid episode. To hear more, visit www.mendelspod.com Is biology headed back into the genome? While much of biology has been expanding outwar

Mass Spec Comes to the Routine Core Lab: Don Mason of Roche on a New Era in Clinical Testing

Mass spectrometry has been one of the most powerful technologies in clinical testing for decades. So why is it still largely confined to specialty labs? Don Mason has sp

Jennifer Dionne Wants to Read the Whole Proteome Using Nanophotonics, i.e. Raman Spectroscopy

This is a free preview of a paid episode. To hear more, visit www.mendelspod.com Jennifer Dionne, Stanford physicist and co-founder of Pumpkinseed, joins us to talk abou

Katie Maloney, Partner at DeciBio Consulting, Sees an Inflection Point for Digital and Computational Pathology

This is a free preview of a paid episode. To hear more, visit www.mendelspod.com Digital technology has been promising to transform pathology for years. But the last yea

It’s One of the Greatest Success Stories of Molecular Medicine. Genomics Historian Kevin Davies on His Latest Book about Casgevy and Sickle Cell Disease

This is a free preview of a paid episode. To hear more, visit www.mendelspod.com It was the heady days of the CRISPR revolution and of the gene therapy Casgevy. And when

Elias Sayour on the Cancer Vaccine Breakthrough

This is a free preview of a paid episode. To hear more, visit www.mendelspod.com After being pursued for more than 150 years, cancer vaccines may finally be having their

What Single Cell Sequencing Revealed About Pulmonary Fibrosis with Nick Banovich, TGen

Single cell sequencing has given researchers extraordinary new maps of human biology. For Nick Banovich of TGen, the burning question is how to turn those maps into somet

The Quest to Measure Protein Function with Polly Fordyce, Stanford

Stanford physicist and bioengineer Polly Fordyce has a big vision. She’s attempting to measure protein function at the scale at which we learned to measure DNA. We can se

Doubling Down on Long Reads: New CEO of PacBio, Mark Van Oene

Mark Van Oene has just taken over as CEO of Pacific Biosciences, and Mendelspod is his first interview in the new job. He began his career as a scientist studying cystic

Serge Saxonov on What’s Next for 10x Genomics

This is a free preview of a paid episode. To hear more, visit www.mendelspod.com 10x Genomics has been remarkably good at figuring out where biology is going next. In t

“You Cannot Discover What You Cannot Make”: Lee Cronin on Programming Chemistry

This is a free preview of a paid episode. To hear more, visit www.mendelspod.com Those of us in biology tend to think that chemistry is rather straight forward. But toda

All of Us Comes of Age. And So Does Its Funding: Josh Denny on the Next Phase of Precision Medicine

There are very few genomics projects with the level of ambition of the NIH All of Us Research Program. The latest release includes data from more than 747,000 participant

Season Opener: Is Biology Having Its Newtonian Moment? with Rob Phillips, Caltech

Welcome to Mendelspod’s 16th season! It’s hard to believe we’ve been doing this for just over 15 years, following first and foremost the people reshaping biology and med