Frameshifts with Benjamin Arya

Lucas Mair on AI, Robotics, and the Future of Fully Automated Biology | Frameshifts Episode #15

This week, my X feed exploded with news that Anthropic had released hardware standards that allow AI agents to operate lab equipment directly. Their new “Model Hardware S

Logan Thrasher Collins: The Trojan Horse That Could Fix Gene Therapy | Frameshifts Episode #14

On this show, we’ve talked a lot about gene editors. These are little molecular machines derived from or inspired by the Nobel-prize winning CRISPR system that put gene e

Joe Betts-LaCroix on Retro, Reprogramming, and the First Real Longevity Drugs | Frameshifts Episode #13

Most longevity talk is still stuck within two bad schools of thought. On one side, weak-sauce incrementalism: supplements, vibes and tiny effect sizes. On the other, immo

Alex Zhavoronkov: Beating Aging, Designing Drugs and Betting on China | Frameshifts Episode #12

Plenty of people will tell you AI is about to design our drugs. Alex Zhavoronkov already has. His company’s lead candidate, rentosertib, is the first drug with both its b

Building Science's Missing Infrastructure — Adam Marblestone | Frameshifts Episode #11

Many of science’s most important projects fall through the cracks between academia and industry. These are the foundational tools that could accelerate entire fields, and

Why 92% of Your Proteins Are Invisible — Parag Mallick | Frameshifts Episode #10

Parag Mallick is a Stanford Professor and Chief Scientist at Nautilus Biotechnology, a publicly traded biotech company. He’s also a professional magician and circus perfo

Building the Wyss Institute, Organs-on-Chips, and Fighting for Science — Don Ingber | Frameshifts Episode #9

The future of human biology isn’t about better animal models - it’s about building human organs on chips that think like the body does. Don Ingber, founding director of

Shelby Newsad: Why Platforms Fail, What Founders Need, and Where Biotech Wins | Frameshifts Episode #8

This week, I sat down with Shelby Newsad, Partner at Compound VC, to break down what makes a great biotech investment and why so many platform stories fall short. Shelby

Space Travel, AI, and Immortality — Peter Diamandis | Frameshifts Episode #7

What happens when the man who launched commercial spaceflight decides humanity needs to stop aging? Peter Diamandis is building the infrastructure to tackle aging. He fo

Minimally Invasive Neurosurgery, Brain-Computer Interfaces, and Continuous Pupil Monitoring — Theodore Schwartz

What happens when one of the world’s leading neurosurgeons steps away from the operating room to become a first-time founder? Dr. Theodore Schwartz pioneered minimally in

Michael Florea: Smart Cages, AAV Cocktails & The Future of Longevity Research | Frameshifts Episode #5

This week, I sat down with genome engineering prodigy Michael Florea. I first met Michael at the Longevity Biotech Fellowship retreat in Tahoe National Forest, Californi

Virtual Cells, Programmable Biology, and the Quest to Hack Human Aging — Omar Abudayyeh & Jonathan Gootenberg

This week, I sat down with Omar Abudayyeh and Jonathan Gootenberg, the co-PIs who helped pioneer the field of genome engineering, and are now leading one of the most inno

Francisco LePort & Martin Borch Jensen: The Biotech Founders Testing 25 Drugs in One Horse | Frameshifts Episode #3

In this week’s episode, I sit down with Francisco LePort and Martin Borch Jensen, the co-founders of Gordian Biotechnology. Gordian is revolutionizing drug discovery by t

Ron Weiss: Building Biological Neural Networks to Fight Cancer | Frameshifts Episode #2

In this week's episode, I sit down with Prof. Ron Weiss, the MIT pioneer who helped create the field of synthetic biology. We discussed the emergence of living therapeuti

Kevin Esvelt: Sculpting Evolution, Engineered Viruses and Safeguarding Biotechnology | Frameshifts Episode #1

“What I wanted to do was harness evolution as effectively as possible.” In this episode, I sit down with pioneering synthetic biologist Kevin Esvelt. Together, we explor

Eldin Rostom: Biotech Entrepreneurship and Becoming a Dad | Insane Ambition Episode #14

Forbes 30 Under 30 honoree, Eldin Rostom, CEO and Co-Founder of Diag-Nose.io, who is pioneering the way forward in the diagnosis of chronic nasal disorders. In this episo

Joe Foster: Founding Reebok & Building a Globally Recognised Brand | Insane Ambition Episode #13

Meet Joe Foster, founder of Reebok, who revolutionised the sportswear industry by building a multi-billion dollar shoe empire. In this episode, Joe recalls his earliest m

Ethan Donati: From Social Anxiety to hosting the World's Top Speakers | Insane Ambition Episode #12

In this episode, we sit down with Ethan Donati, a marketing expert who overcame social anxiety to host some of Australia's largest events. Ethan shares his journey from a

Michael Batko: Rethinking Startups & Shaping Tomorrow's Tech Giants | Insane Ambition Episode #11

Step into the world of startup transformation with Michael Batko, the visionary CEO behind Startmate. With a track record of nurturing 230+ startups valued at over $2 bil

Jane Gunn: Future of Australia’s Health System & Primary Care Crisis | Insane Ambition Episode #10

Joining us is the inaugural chair of Primary Care Research at Royal Melbourne Hospital, Jane Gunn. Known not only as a medical practitioner and PhD graduate, Jane is also