Precision Signals

Peter Kolchinsky, PhD: Ideas That Refuse to Die

In the latest episode of Precision Signals, Sean Khozin speaks with Peter Kolchinsky, founder and managing partner of RA Capital Management. Peter’s perspective is shape

Thomas Clozel, MD on Building Intelligence that Reads Life

There is a sentence most physicians are trained never to say. Three words: I don't know. Thomas Clozel learned early — from Valentin Fuster at Mount Sinai — that those th

Everything is a Signal: Sahir Ali on Connecting AI, Biology, and Venture Capital

Sahir Ali’s career defies conventional paths. Trained as an engineer, he worked in quantitative finance, contributed to cancer research, built software companies, and ult

Navigating Change: Coach K's Perspective on Leadership in Modern Times

In this episode of Precision Signals, we speak with Mike Krzyzewski, known to most of the world as Coach K, about leadership, trust, teams, cancer advocacy, and the human

Dr. Brian Druker on Gleevec, Precision Oncology, and the Future of Cancer Research

Dr. Brian Druker helped change the course of modern oncology through his central role in the development of imatinib (Gleevec), a therapy that transformed chronic myeloid

Leading the Charge in Oncology: A Conversation with ASCO's Dr. Clifford Hudis

In this episode of Precision Signals, Sean Khozin, MD, MPH sits down with Clifford A. Hudis, MD, FACP, FASCO, CEO of the American Society of Clinical Oncology (ASCO), to

Sunil Verma on ADCs, AstraZeneca, and Eliminating Cancer as a Cause of Death

Sunil Verma, SVP and Global Head of Oncology at AstraZeneca, has lived a life defined by reinvention. Born in Zambia, raised across Africa, India, and Canada, he was acce

Beyond Survival: The Architecture of Cancer Immunotherapies

As cancer treatments become more powerful and precise, the field of oncology is entering a new era. We are moving beyond the question of "Can we extend life?" to "How do

David Fajgenbaum: Surviving Castleman Disease and Reinventing Drug Discovery with AI

In this episode of Precision Signals, Sean Khozin sits down with Dr. David Fajgenbaum — physician, scientist, patient, and founder of Every Cure — to explore one of the m

Why Sean Parker Took on Cancer: Funding Risk, Failure, and Real Progress

Most people know Sean Parker as the prodigy behind Napster and Facebook. Far fewer know why he chose to take on one of the hardest problems in science: cancer. In this cl

Sushil Patel, CEO of Replimune: The Future of Cancer Immunotherapy

Sean Khozin in a conversation with Sushil (Sush) Patel, CEO of Replimune, discussing advancements in cancer immunotherapy, particularly the use of oncolytic viruses. They

Dan MacHugh: From Bench to Boardroom

In this episode of Precision Signals, Sean Khozin speaks with Dan McHugh, investor at Yosemite, about the systems that mediate between scientific discovery and patient im

Leading at Every Altitude

Dr. Karen Knudsen, CEO of the Parker Institute for Cancer Immunotherapy (PICI), joins Dr. Sean Khozin to dissect the science and business of curing cancer. From her upbri

Everything Is Changing Everywhere | Daniel Arbess on Institutional Innovation in Healthcare

In Episode 4 of Precision Signals, Dr. Sean Khozin sits down with Daniel Arbess—investor, social entrepreneur, and healthcare innovator—to explore why the limiting factor

Endpoints, Resistance, and the Architecture of Evidence in Immuno-Oncology

In this episode of Precision Signals, Dr. Sean Khozin speaks with Dr. James Gulley, Chief of the Medical Oncology Service and Co-Director of the Center for Immuno-Oncolog

The Mission is the Boss

Dr. Michelle Longmire, physician-scientist, technologist, and CEO, cofounder of Medable; shares how early lessons in science and systems design shaped her mission to fix

AI in Oncology: Hype, Evidence, and the Threshold of Clinical Trust

What does it take for AI to move from technical innovation to real-world adoption in oncology? In the first episode of Precision Signals, Dr. Sean Khozin speaks with Dr.