EP Edge™ In Depth: Topical Cardiac Electrophysiology Research artwork

Life Sciences · Niraj Sharma MD FACC FHRS: Cardiac Electrophysiology & Cardiology

EP Edge™ In Depth: Topical Cardiac Electrophysiology Research

by Niraj Sharma MD FACC FHRS: Cardiac Electrophysiology & Cardiology

Monthly clinical deep analysis in cardiac electrophysiology: AF, VT, SVT, ablation, devices, antiarrhythmic drugs, and high-impact trials. In Depth: physician-level analysis that identifies what matters in EP and translates evidence into clinical practice. EP Edge™: In Depth is the flagship monthly podcast from EP Edge, delivering structured, expert-level interpretation for electrophysiologists, cardiologists, fellows, and clinically engaged practitioners. Each episode goes beyond summaries to integrate evidence across trials, guidelines, mechanisms, and real-world practice. Episodes cover the full spectrum of electrophysiology, arrhythmia including atrial and ventricular arrhythmias, supraventricular tachycardias, antiarrhythmic pharmacology, pacing and defibrillator strategies, mapping and ablation technologies (including pulsed field ablation), and emerging data shaping clinical decision-making. This is not a news recap—it is a curated synthesis focused on what truly changes practice. Content combines mechanistic insight, cross-trial evidence review, critical appraisal of methodology and outcomes, and practical application in the EP lab and clinic. EP Edge™: The Signal complements the weekly EP Edge™: Journal Watch by providing deeper analysis and clinical synthesis. For patient-focused education, explore EP Edge™: Heart Talk. Available as both podcast and newsletter via EP Edge on LinkedIn and Substack: https://epedge.substack.com/

Chart trend

Position in the Life Sciences chart (US), last 90 days.

#23
all-time peak
17
days in the top 50 since Oct 2025

Latest episodes

Showing 11 · updated from the feed

EP Edge Newsletter Part III: Pulsed Field Ablation Complications — Hemolysis, Coronary Spasm, Silent Stroke, Phrenic Nerve Injury, and CIED Interaction

Pulsed field ablation (PFA) has rapidly transformed atrial fibrillation ablation, offering a non-thermal mechanism of myocardial injury through irreversible electroporati

Feb 25
30 min

EP Edge Newsletter Part II: Pulsed Field Ablation Trials — ADVENT, PULSED AF, Sphere-9, VARIPULSE, VOLT, INSIGHT, and PULSAR

In this episode of the EP Edge Newsletter Podcast, we analyze the pivotal clinical trials that established pulsed field ablation (PFA) as a major technological advancemen

Feb 18
42 min

EP Edge Newsletter Part I: Pulsed Field Ablation (PFA) — Electroporation, Biophysics, Engineering, Tissue Selectivity, and Lesion Formation

In this foundational episode of the EP Edge Newsletter Podcast, we examine the scientific and engineering principles underlying pulsed field ablation (PFA), a transformat

Feb 11
20 min

Cannabis and the Heart: Atrial Fibrillation, Arrhythmias, Stroke, Myocardial Infarction and Sudden Cardiac Risk Explained

In this EP-EDGE podcast episode, Dr. Niraj Sharma, cardiac electrophysiologist, breaks down the latest evidence linking modern high-THC cannabis to cardiovascular and ele

Dec 22 2025
24 min

When Atrial Fibrillation Ablation Fails: Have We Reached the Limit or Just the Wrong Target?

In this issue, we trace the fascinating evolution of atrial fibrillation (AF) therapy — from the Cox Maze procedure to Haïssaguerre’s discovery of pulmonary vein ectopy,

Nov 23 2025
11 min

Targeting the Intrinsic Pathway: Is Factor XI Inhibition Poised to Redefine Stroke Prevention in AF: EP Edge August 2025 Issue 4A

What if stroke prevention in atrial fibrillation no longer meant trading protection for bleeding risk? Factor XI inhibition—led by trials like AZALEA–TIMI 71, LILAC–TIMI

Oct 28 2025
10 min

First-Line VT Ablation: Trials, Tools & Timing: EP Edge Newsletter June 2025

The paradigm is shifting. Ventricular tachycardia (VT) ablation is stepping out of the shadows—from rescue therapy to first-line strategy, driven by landmark trials like

Oct 28 2025
8 min

Left Atrial Appendage Occlusion (LAAO): Where We Stand in 2025: EP Edge Newsletter 4B August 2025

Left atrial appendage occlusion (LAAO) has evolved from a niche option for oral anticoagulation–intolerant patients to a frontline procedural strategy for stroke preventi

Oct 28 2025
9 min

Pulse Field Ablation: Promise, Peril, and the AI Revolution in EP: EP Edge Newsletter May 2025

Pulse field ablation (PFA) has been hailed as the next frontier in atrial fibrillation therapy—nonthermal, ultra-selective, and lightning fast. But as new data emerges, i

Oct 28 2025
9 min

Lifestyle Modification and Atrial Fibrillation: Redefining the role of the Electrophysiologist: EP Edge Newsletter July 2025

Ablation is powerful—but lifestyle is transformative. As atrial fibrillation (AF) continues to rise globally, emerging evidence makes it clear: lifestyle modification is

Oct 28 2025
14 min

Beyond CRT: LBBAP and the New Era of Physiological Pacing — Promise and Pitfalls: EP Edge Newsletter October 2025 Issue 5

In this episode of EP Edge Podcast, Dr. Niraj Sharma dives deep into the clinical promise and procedural realities of LBBAP: Clinical advantages: improved LVEF, narrower

Oct 27 2025
10 min

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#165 ▼ 55 Life Sciences US

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