Absolute Gene-ius

Better together – how qPCR and dPCR complement each other

Choosing between qPCR and digital PCR isn't about finding a winner, it's about asking the right scientific question. In this Science Snapshot, Jordan Ruggieri and Lisa C

Multiplexing qPCR without multiplying the complexity

PCR gets amplified, quantified, partitioned, and multiplexed in this practical tour through three decades of molecular biology innovation. Dr. John Pfeifer, senior real-

Beyond the band – understanding copy number variation

In this Science Snapshot, we explore copy number variation (CNV) and why accurately measuring gene copies is critical for modern research. Jordan Ruggieri and Lisa Crawf

qPCR, nested PCR, and the search for bacterial serotypes

Some science stories start with a textbook. Donna Paznar’s started with a tick. In this episode of Absolute Gene-ius, Donna Paznar, head of Molecular Infection Diagnosti

How PCR, CRISPR, and animal models are advancing oncology research

Cancer research is moving fast, and molecular tools are helping scientists see more, measure more, and ask better questions. In this Science Snapshot episode of Absolute

Genotoxicity, vectors, and the power of integration site analysis

In this episode, Michael Stump and Matteo Franco from ProtaGene explore the growing importance of integration site analysis (ISA) in cell and gene therapy. As viral vecto

From brewing to bioprocessing – Steve Lewis on molecular biology trends

PCR may be decades old, but it is still one of the most versatile tools in modern molecular biology. In this crossover episode, Absolute Gene-ius welcomes Steve Lewis, h

Epigenetics unlocked – how behavior shapes biology

Dr. Robert Philibert joins the show to unpack the fascinating world of epigenetics, where environmental factors like smoking, alcohol, and lifestyle reshape how genes are

Multiplexing in action – from simplicity to scientific complexity

Multiplexing is reshaping how scientists think about PCR experiments, turning single-target workflows into powerful, multi-dimensional analyses. In this Science Snapshot

Finding the cheat codes to cell identity

In this episode, Fiona Connolly, former Platform Innovation and Automation Scientist at bit.bio, explains how deterministic programming replaces the traditional “pinball

Science happens, and so do mistakes

Science doesn’t just advance through breakthroughs, it advances through mistakes. This Science Snapshot episode embraces a universal truth of research: if you haven’t mes

Almost a virus – how AAV powers modern gene therapy

Viruses are not always something to fear; they can also be tools to heal. This episode looks into this positive side of viral biology. Dr. Dan Mitchell, Senior Director

How sequencing and PCR work together in oncology research

In this episode of Absolute Gene-ius, the hosts dive into the evolving world of precision oncology, where detecting rare molecular signals can make all the difference. D

When PCR gets dirty - tackling PCR inhibitors

PCR inhibitors are everywhere and they can definitely mess with your data. From muddy lake water to complex viral vector preparations, inhibition is a reality that can’t

Tracking grape pathogens from air to vine

What do vineyards, airborne spores, and digital PCR have in common? Turns out – quite a lot. This episode kicks off Season 4 by going green with plant pathology and molec

Season 4 – new voices, new discoveries

We’re back and better than ever. Season 4 of Absolute Gene-ius is officially here, and this teaser gives you a front-row seat to what’s coming. From scientific puns to sn

Digital PCR and the fight against HIV-2 and superbugs

HIV, superbugs, and standards—oh my! In this episode of Absolute Gene-ius, we explore the frontier of infectious disease research with Dr. Jesús Mingorance, researcher at

Biomarkers in motion ― detecting Alzheimer's through saliva

Can you detect Alzheimer’s with a spit sample? That’s the question driving Arianna Arbona’s exciting research at Universidad Pablo de Olavide in Sevilla, Spain. In this e

Python problems – digital PCR takes on the Everglades

This episode of Absolute Gene-ius slithers into the surprising science of invasive species monitoring with Dr. Brian Bahder. A childhood love of bugs led Brian to a dynam

Life finds a way – copy number variation and drug metabolism

Ever thought about why medications work differently for different people? In this episode of Absolute Gene-ius, we explore the exciting field of pharmacogenomics with Wen