Pharm to Table

SE5:E3: A Process Chemist's Romance with Scaling a Macrocyclic Peptide

Last episode, we watched medicinal chemistry dream up enclitide (MK-0616) — this week we find out what happens when someone actually has to make it. Dani and LC are joine

SE5:E2: The Macrocyclic Mullet

What happens when the textbook SAR playbook stops working? On this episode of Pharm to Table, Rob Garbaccio joins Dani and LC to share the discovery story behind enliciti

SE5:E1 - A Journey of Synthetic Chemistry Innovations at Merck

To kick off Season 5, Dani and LC discuss a recent perspective published in the Journal of Organic Chemistry that highlights innovations in synthetic chemistry which trac

SE4:E8: From Discovery to Process, Part 2: Getting Ugi with it - scaling a 3CL protease inhibitor

In Part 2 of our Pharm to Table deep dive on MK‑7845, Dani and LC shift from invention to implementation, welcoming process chemists Nastaran Salehi Marzijarani and Ben T

SE4:E7: From Discovery to Process, Part 1: Building a 3CL Protease Inhibitor Through Smart Fluorine Placement and Design Intuition

In this first installment of our two‑part Pharm to Table special on MK‑7845, Dani and LC sit down with medicinal chemist Valerie Shurtleff to unpack the discovery journey

SE4:E6 - Mechanism-Driven Innovation in Process Research: Yining Ji Chen’s Road as a Rising Star

Join us for a conversation with Yining Ji Chen, recipient of the 2025 ACS Rising Star Award, on how mechanistic insight powers innovation in pharmaceutical process resear

SE4:E5 - Evolution of a Green Chemistry Trailblazer

In this episode, Dani and LC welcome Jeff Moore, recipient of the 2025 ACS Affordable Green Chemistry Award, to discuss his pioneering work in biocatalysis at Merck. The

SE4:E4 - MedChem Masters: Molecules, Mentors and Mindsets

In this episode, Dani and LC interview Dr. Shane Krska, recipient of the ACS Arthur C. Cope Award, and Dr. Petr Vachal, recipient of the ACS Earle B. Barnes Award for Lea

S4:E3 - London Calling ... Spirocycles

This month we sit down with Damien Valette, Olivia Boyd and David Petrone to chat about their latest paper in Organic Letters on the desymmetrization of prochiral dienone

S4:E2 - Making Sulfur Smell like Success!

Join us on the Pharm to Table podcast for a delightful chat with Ethan Wappes from our South San Francisco site, as we dive into the exciting world of thiophene synthesis

S4:E1 Chemistry Unplugged: Listener Q&A and Future Insights

We're kicking off Season 4 (holy cow!) by having a lively discussion answering listener questions on everything from our favorite Boc deprotection methods to the role of

S3:E10 - Look what ADCs made us do

Antibody drug conjugates, or ADCs, are all the rage in the industry right now and chemists play an important role in their development. This month we sat down with Serge

S3:E9 - Surfing peptide production by going with the flow

Ready to go with the flow? Then this episode is for you! In this episode, we dive into the exciting world of Continuous-Flow Solid-Phase Peptide Synthesis (CF-SPPS) with

S3:E8 - So you think you want to start a chemistry podcast?

Join Dani and LC as they peel back the layers on podcasting in chemistry. This insightful episode dives into their recently published Organic Letters editorial "Should Yo

S3:E7 - Your Rx for a Pharma Job: Insider Secrets (Part 2)

Time for the main course! Our #MerckChemistry hiring experts are dishing out more savory tips to help you get hired in pharma. In this second part, they'll guide you thr

S3:E6 - Your Rx for a Pharma Job: Insider Secrets (Part 1)

Looking to kickstart your career in the pharmaceutical industry? This episode is a must-listen! We have special guests Jamie McCabe Dunn, Val Shurtleff and our very own D

S3:E5 - When Robots Work-It-Up!

Alexandra Sun and Harrison Rose join the pod to share their work on a vision-guided automated liquid-liquid extraction (LLE) platform. That's right, before our robot over

S3:E4 - "Asta La Vista, Baby" - The Aminator

Patrick Fier and Suhon Kim join the pod to share their lates collaboration on a new C-N cross-coupling protocol which leverages a novel multifunctional template reagent.

S3:E3 - A chemist, a physicist and an enzyme walk into a bar...

Nadine Kuhl (process chemist) and Jacob Forstater (engineer and physicist) join the pod to share a pretty neat story that had its origins from a chemical catalog brochure

S3:E2 - Barton-McCombie Beware!

Charles Yeung (@Charles_chem) joins the pod to share some of the latest results from a collaboration with Prof. Wickens' lab (@WickensGroup) at the University of Wisconsi